This movie is of Hally, an adolescent white South African. He is stuck between his intolerant father's outlook of him and those of his caretaker, Sam. Sam is a black waiter and Hally's friend and teacher. Hally is required to laugh at his father's racist jokes, by contrast, Sam exposes Hally to uplifting experiences. One day Hally was terribly humiliated by his father and Sam shows Hally how to be proud of something he can achieve.

In Johannesburg, the small time criminal Tsotsi is a teenager without feelings, hardened by his tough life. After killing a man with his gang in a robbery; hitting the gangster Boston of his gang; humiliating a crippled beggar along one night, Tsotsi hijacks a car and under the despair of a woman, he shoots her in the stomach. While driving the car, Tsotsi finds that there is a baby on the back seat and the woman was a desperate mother. He brings the baby to his house in the slum and becomes attached to him. For six days, the baby changes his behavior, arousing and developing the sense of empathy and humanity in the cold blood killer.